This review will summarize the background, technology and recent history of the search for genes and describe the exciting promise of its future impact on clinical practice. After this period of scientific depression, the outlook has recently begun to improve based on several new developments. Bipolar disorder is a mental health condition. Call our toll-free, hour helpline right now to speak to an admissions counselor who can provide you with the necessary resources you need to get better. Chromosome 18 DNA markers and manic-depressive illness:
It is the development of DNA marker technology that made genetic mapping possible. The role of genes is indicated by a higher concordance rate among MZ twins, who share all their genes, compared to DZ twins. In their replication of the chromosome 18 linkage, Stine and others found the strongest evidence of linkage in families in which illness was transmitted through the fathers rather than the mothers. In short, the hope is that current genetic research may be the stepping stone to a new era of biological psychiatry based on much more specific knowledge and treatment of this debilitating illness. Synopsis of Psychiatry, sixth edition. No fear of consequences Most individuals who experience hypomania often find that during this period of time, they are not concerned with the consequences of their actions. A strong connection exists between the incidence of the disorder in individuals and occurrence in their biological parents. A genetically based knowledge of pathophysiology may also lead to a very different diagnostic system based on different disease mechanisms. Another report indicated a gene on chromosome 11 for bipolar disorder may have been detected in one non-Amish family. The partner with bipolar may feel distraught over having hurt the other partner, who in turn feels confused and angry for having been cheated on. Now, a recent report by a Finnish group of linkage to X chromosome markers brings renewed interest to this chromosome Pekkarinen and others , as has the work of a French group Lucotte and coworkers. A variety of epidemiological data had for many years suggested the possibility of a gene for bipolar disorder on the X chromosome. Stimulants in particular can be problematic: Over many decades, numerous epidemiological studies have pointed to the likely role of genetic factors in the predisposition to bipolar disorder Tsuang and Faraone. People with bipolar disorder can alternate between periods of positive moods, called mania, and negative moods, called depression. What lies ahead in the search for bipolar genes? It appears that the evidence for a genetic cause of bipolar affective disorder is stronger than that for depression. Twin, adoption, and family studies indicate genetics play an important role in the expression of affective disorders. This, coupled with their increased hypersexuality, can lead to sexual binges and dangerous sexual encounters that can harm them physically, as well as harm their significant others emotionally. The researchers found strong evidence of linkage to the Xq28 region. Subsequent experience seemed to defy this expectation. This may lead to a better understanding of the mechanism of action of current therapeutic agents, and may identify targets for the development of new drugs. The mode of inheritance for bipolar disorder in this family must be autosomal recessive. Though these data indicate that bipolar disorder is familial, they do not prove that it is genetic. Finally, the environmental factors influencing expression of bipolar affective disorder should not be overlooked.
Video about is bipolar sex linked trait:
X Linked Recessive
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