Mary Heitzeg of the University of Michigan to undertake a systematic review of more than published HIV cure research studies. Home What is intersex? By the way, because some forms of intersex signal underlying metabolic concerns, a person who thinks she or he might be intersex should seek a diagnosis and find out if she or he needs professional healthcare. She soon realized, however, that there were very little available data on the topic. For example, a person might be born appearing to be female on the outside, but having mostly male-typical anatomy on the inside. It suggests that women may respond differently than men to some curative interventions that are currently under investigation or, perhaps, that an effective cure for women could differ from a cure for men. And some think you have to have both ovarian and testicular tissue to count as intersex. The reservoir of HIV that is impervious to antiretroviral therapy remains the principal barrier to a cure.
By the way, because some forms of intersex signal underlying metabolic concerns, a person who thinks she or he might be intersex should seek a diagnosis and find out if she or he needs professional healthcare. We work to build a world free of shame, secrecy, and unwanted genital surgeries for anyone born with what someone believes to be non-standard sexual anatomy. Given their smaller inducible reservoir, would such a strategy be less effective in women? Some people live and die with intersex anatomy without anyone including themselves ever knowing. In practice, different people have different answers to that question. We have cross-posted it with their permission. Their first set of findings, detailed in the PNAS paper, lay the groundwork for a preliminary trial to evaluate the effectiveness of the drug tamoxifen combined with the latency-reversing agent vorinostat in reactivating latent HIV in women. In other words, while the total size of the reservoir appears to be the same for both sexes, women have a smaller amount of reservoir virus that can be coaxed out of hiding by so-called latency-reversing agents LRAs. It suggests that women may respond differently than men to some curative interventions that are currently under investigation or, perhaps, that an effective cure for women could differ from a cure for men. Eileen Scully of Massachusetts General Hospital to explore how sex-based differences might affect the HIV reservoir and, by extension, a potential cure. First, one of the main cure strategies being pursued by researchers is "shock and kill" or "kick and kill". Humans decide whether a person with XXY chromosomes or XY chromosomes and androgen insensitivity will count as intersex. In the same way, nature presents us with sex anatomy spectrums. Johnston was invited to give a talk on sex differences in HIV cure research at a conference. Rather than trying to play a semantic game that never ends, we at ISNA take a pragmatic approach to the question of who counts as intersex. Home What is intersex? This article was originally published by amfAR on Aug. Humans today, typically doctors decide how small a penis has to be, or how unusual a combination of parts has to be, before it counts as intersex. Advertisement Second, since reactivation of the reservoir is inhibited by estrogen, the researchers suggest that "studies of the impact of hormonal contraception on reservoir establishment and its long-term maintenance should be undertaken. Jonathan Karn of Case Western Reserve University, found that women have a smaller "inducible" reservoir than men. The researchers were tasked with comparing the key differences in latent virus in men and women, and exploring the immune profile, activation levels and distribution of latent viral reservoirs in men versus women. But in human cultures, sex categories get simplified into male, female, and sometimes intersex, in order to simplify social interactions, express what we know and feel, and maintain order. Intersex is a socially constructed category that reflects real biological variation. So she teamed up with Dr. Or a person may be born with genitals that seem to be in-between the usual male and female types—for example, a girl may be born with a noticeably large clitoris, or lacking a vaginal opening, or a boy may be born with a notably small penis, or with a scrotum that is divided so that it has formed more like labia. Following a cohort of 26 men and 26 women, the researchers, led by Dr.
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